NAME: Adrian Lapthorn
AFFILIATION: University of Glasgow, UK
CONTACT: adrian@chem.gla.ac.uk
TITLE: "N-body Molecular Replacement: Solution of a Super Lattice Structure"
ABSTRACT: Solving a structure by molecular replacement with multiple copies of the protein within the asymmetric unit is not necessarily problematic using current automated methods. What is possible in an ideal situation where an accurate search model is available and complete redundant x-ray data has been collected? What are the limits to how small a fraction of the asymmetric unit contents can be searched for? An example of a super lattice structure of type II dehydroquinase will be discussed which has 192 molecules (16 dodecamers) in the asymmetric unit.